One caller challenged Mr Farage as he asked if there was anything which would make the former Ukip leader change his mind about the European Union exit.
Joe in Brighton asked: “Just a hypothetical question for you if I may if you had a crystal ball and you could foresee that leaving the EU would be more negative to the United Kingdom than positive… would you still want to go ahead with exiting.
“Even if you could foresee, I know that’s not the case right now, I just want to know.”
Nigel Farage said he was certain the EU will fail on LBC
Appearing amused, the LBC host responded there were no such scenarios as he said the one thing he was sure about what the EU crumbling.
Mr Farage said: “Well hypothetically, Joe, are there circumstances that would make me think it is wrong to leave a club that has no democratic legitimacy, that has taken away our birthright?
“I don’t foresee any circumstances in which I’m going to think that.
“You know we might get good governments in this country, we might get bad governments in this country but what I am absolutely… I am as certain that the European Union will fail as I was the United Kingdom should leave it and just look at the mess it’s in right now.”
I am as certain that the EU will fail as I was the UK should leave it
The LBC host also dismissed claims he had abandoned Brexit ahead of talks with Brussels, as he told his listeners he would be championing the cause in the European Parliament.
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Mr Farage said: “What is going to really matter from Wednesday for the next two years is what happens in Brussels and what happens in the European Parliament and I am going to go on leading a group in the European Parliament.
“I am going to go on travelling around Europe, I am going to do more speaking in provincial towns and cities where there are car workers, where there are people who work in the wine industry, the chocolate industry, saying to them put pressure on your MEPs and your prime ministers because actually, a sensible trade deal works for both of us.”
It comes as Theresa May on Monday reiterated to Nicola Sturgeon that "now is not the time" for a second independence referendum as the pair began talks in Glasgow's Crown Plaza Hotel.
Theresa May's most powerful quotes Fri, March 10, 2017 Getty Images 1 of 8
'I will be ruthless in cutting out waste, streamlining structures and improving efficiency'
The Prime Minister is adamant her position "will not change" with regard to Scottish independence, saying Brexit is more important.
Earlier, she said: "My position is very simple and it hasn't changed. It is that now is not the time to be talking about a second independence referendum and that's for a couple of reasons.
"First of all, now is the point when we are triggering Article 50, we're starting negotiations for leaving the European Union. Now is the time when we should be pulling together, not hanging apart. Pulling together to make sure we get the best possible deal for the whole of the UK.
"Also I think it would be unfair on the people of Scotland to ask them to make a significant decision until all the facts were known, at a point where nobody knows what the situation is going to be.
"My position isn't going to change, which is that now is not the time to be talking about a second independence referendum."