The 36-year-old presenter was reduced to stitches mid-way through a link after co-host Phillip Schofield set her off laughing.
During a link informing viewers of what else was coming up on the latest edition of the ITV show, her co-host was heard saying: “You can taste Fearne’s cupcakes at 12.15.”
However, the Great British Bake Off-style innuendo set Phillip, 55, off and he could not control his giggles.
His hysterics led Holly to start giggling and she was seen crouching down on the studio floor as she laughed uncontrollably: “The coffee’s kicked in!”
“I can’t believe you’re doing this, you’re doing it on telly! You’re doing that so you don’t wet yourself!” Phillip, 55, was heard exclaiming to his fellow This Morning star.
After finally getting through the link, the camera lingered on the ITV hosting duo as they struggled to compose themselves , leading Phillip to say: “Run VT, for god’s sake!”
Holly Willoughby was in stitches on This Morning
Holly Willoughby and Phillip Schofield could not stop laughing on This Morning
I can’t believe you’re doing this, you’re doing it on telly! You’re doing that so you don’t wet yourself!
The pair seemed to have burst into stitches partly because of drinking extra-strong coffee earlier on in the show.
“I’ve gone super-hyper,” Holly told viewers afterwards, when she was finally straight-faced once more.
Get Quotes on Home Insurance
The scenes come after another funny moment on This Morning yesterday when Phillip was left red-faced when Holly shared a throwback video of him from the 80s.
Phillip Schofield was left in hysterics on This Morning This Morning: The funniest moments Mon, December 12, 2016
This Morning: Laughter, tears and nudity, the most outrageous moments from the ITV show.
ITV 1 of 31
The funniest moments on This Morning
In the video footage, Phillip was wearing a big pair of glasses and was compared to Brains from Thunderbirds.
She revealed the embarrassing clip to the nation, leading him to tweet her a sweary message in which he wrote: "You utter s****! Love from Brains."
This Morning airs weekdays on ITV at 10.30am.