A man wearing blue jeans and a black jacket, fled the murder scene in Offenbach in a small dark-coloured getaway car.
Police were alerted to the scene just after 8am (local time) on Friday morning.
The suspect said to be aged between 30 and 40 and thought to be armed.
German Police have launched a major manhunt
The attack took place on Ottersfuhrstraße
Police have deployed a search helicopter and appealed for the public to be vigilant as the gunman remains at large.
The reason for the crime is currently unknown.
Officers are also looking for the man beyond the city borders.
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