Emmanuel Macron and Marine Le Pen are going head to head in the election
The 39-year-old En Marche! politician was condemned for his rookie error after describing French Guiana as an island.
It comes just weeks after he flew to Algeria and apologised for French colonisation and was slammed by critics back home.
This latest geographical gaffe came after Mr Macron was asked to give his opinion as 37 labour unions plan strike action which will paralyse the small French department.
Sometimes even blocking off the function of the island itself is not the response to the situation
Mr Macron said: "What's been happening in French Guiana over the past few days is serious.
"My first response is a call for calm, because blocking the airport runways and takeoffs – and sometimes even blocking off the function of the island itself is not the response to the situation."
French Guiana is an overseas region of France on the northeast coast of South America, composed mainly of tropical rainforest.
Mr Macron made an error of geography this week
It is not an island and is instead situated on the Atlantic coast.
Almost as soon as Mr Macron had made the ill-judged comment users flocked to social media to question his comments.
One You Tube user wrote: “He wants to become president… Go learn some geography first!”
Mr Macron has been meeting with potential voters
While another wrote: "It’s you Macron, who is a grave [situation]! You want to be the president of our country, and you think that Guiana is an island! Our French [citizens] of Guiana will be pleased.”
In February, Mr Macron was in Algeria when he made controversial comments which were immediately slammed back home.
He was referencing French rule in Algeria which ran for 132 years until it won a bloody war of independence in 1962.
He said: "It is a crime, a crime against humanity, it is a real barbarism.
"And it's part of the past and now we have to look forward and present our apologies regarding those to whom we have committed these acts. "
The news comes after Swiss bank UBS warned euro zone stocks could crash up to 35 per cent and the euro could tumble 10 per cent in the event that far-right Front National candidate Marine Le Pen wins the French presidential election.
Mrs Le Pen is not projected to win the election
The elections on April 23 and May 7 represent the main political risk event for the euro zone this year due to the popularity of Le Pen, who is running on a platform pursuing France's exit from the euro and European Union.
The prospect of her winning in May remains low according to opinion polls – centrist Emmanuel Macron would trounce her in the second round 62 percent to 38 percent, an Ipsos survey suggested on Tuesday.
But the impact her victory would potentially have on financial markets is "too important to ignore”, said the analysts.
Who will be the next President of France? Mon, March 20, 2017
Candidates for the 2017 French Presidential Election revealed
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The report said: "The assumption of the Presidential office by a politician whose main objective is France's exit from the euro zone/EU implies significant and hard to predict re-denomination and default risks with potential global spill-over effects.
"In addition, the systemic importance of France for the European project is such that the margin for damage limitation may well be a lot thinner than has been the case in Greece in the past or could be the case for Spain or Italy even."