The former Newsnight correspondent and Channel 4 economics editor accused the Conservatives of “dog whistle racism” for their criticism of the shadow home secretary.
The broadcaster became embroiled in a fiery row with former Tory politician and LBC host Iain Dale while appearing as a guest on the BBC show.
Defending Jeremy Corbyn's party, he said: “Labour supports the rule of law, anti-terror and the national security of this country.”
Dale hit back and replied: “Talk to Diane Abbott about that.”
Paul Mason branded jibes at Diane Abbott "racist"
Why is it that you’re picking on Diane Abbott? What’s this racism with Diane Abbott?
Mason then asked: “Why is it that you’re picking on Diane Abbott? What’s this racism with Diane Abbott?”
Dale replied: “She’s unfit to be Home Secretary,” before Mr Mason added: “Why do you hate a black Home Secretary?”
The radio host then accused him of “playing the race card” before the segment was cut short.
It comes after Theresa May took aim at Ms Abbott during her appearance on the BBC’s Question Time Special on Friday.
Diane Abbott's most controversial quotes Fri, April 7, 2017
Outspoken Shadow Home Secretary, Diane Abbott holds strong opinions which does not always go down well.
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Abortion is an issue of conscience for the Labour party.
Iain Dale accused Paul Mason of "playing the race card"
After speaking about her stint as Home Secretary, she said: “I made sure that we kept the records of criminals and terrorists on the DNA database, whereas Diane Abbott wants to wipe them clean.
“I don't think that's a good idea because they help us catch criminals."
She also referred to the Labour politician’s car-crash interview in which she was unable to say how much Labour’s pledge to increase police officer numbers would cost.
She said a Labour government would see “Diane Abbott, who can’t add up, sitting around the cabinet table”.
During the programme, Ms Abbott responded on Twitter: “Desperate stuff by May. Claims I want to wipe DNA database clean. Never said that. Curious that she is singling me out for attack #BBCQT.”
She later quoted Mr Corbyn saying that “a society that cannot challenge racism is a society heading for division”.
Corbyn supporter Mason also took to Twitter and said: “You know what. It's time somebody called out the dog whistle racism behind Tory insults to Diane Abbott and I just decided to do it.”