Andy Murray and Stan Wawrinka are both trying to nab their fourth round spot at the French Open 2017
Murray has been made to work by both of his opponents in Paris so far this week, having dropped a set each to Andrey Kuznetsov and Martin Klizan.
Del Potro meanwhile was given much of Thursday off when his second round opponent Nicolas Almagro was forced to retire in tears during the third set of their clash.
After Murray v Del Potro, Court Phillipe Chatrier will have to split its loyalties in an all-French encounter with Richard Gasquet taking on Gael Monfils.
Saturday will also see No3 seed Stan Wawrinka play for a place in the fourth round against Fabio Fognini while Karolina Pliskova is the top women's seed in singles action as she plays Carina Witthoeft of Germany.
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French Open 2017 Saturday schedule
Court Philippe Chatrier (play starts at 10am BST)
Alize Cornet (France) v 9-Agnieszka Radwanska (Poland)
1-Andy Murray (Britain) v 29-Juan Martin Del Potro (Argentina)
24-Richard Gasquet (France) v Gael Monfils (France)
5-Elina Svitolina (Ukraine) v Magda Linette (Poland)
Court Suzanne Lenglen
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Feliciano Lopez (Spain) v 7-Marin Cilic (Croatia)
26-Daria Kasatkina (Russia) v 3-Simona Halep (Romania)
3-Stan Wawrinka (Switzerland) v 28-Fabio Fognini (Italy)
Andy Murray is hoping to overcome his 2017 clay court struggles
17-Anastasija Sevastova (Latvia) v Petra Martic (Croatia)
Hsieh Su-Wei (Taiwan) v 28-Caroline Garcia (France)
Chung Hyeon (South Korea) v 8-Kei Nishikori (Japan)
Carina Witthoeft (Germany) v 2-Karolina Pliskova (Czech Republic)
Kyle Edmund (Britain) v Kevin Anderson (South Africa)
21-John Isner (US) v Karen Khachanov (Russia)
Veronica Cepede Royg (Paraguay) v Mariana Duque-Marino (Colombia)
14-Elena Vesnina (Russia) v 21-Carla Suarez Navarro (Spain)
Fernando Verdasco (Spain) v 22-Pablo Cuevas (Uruguay)