The violent protest delayed the Front National rally
The protesters, who were mainly young people, sported masks, hoods and even helmets while launching firecrackers in the direction of the police.
Banners read: “The Extreme Right, you can’t fight at the ballot box.”
Ms Le Pen held the meeting to galvanise as much support as possible before the first round of elections on Sunday.
The riot police tried to control the protesters
Marine Le Pen coming to Marseille, a city of strong immigration, is provocation
The police sprayed tear gas on the protesters, who delayed the start of the rally.
One protester, Marie, said: “Marine Le Pen coming to Marseille, a city of strong immigration, is provocation.
“I protest because when the extreme right is in power, it will be over.”
The rally was Marine Le Pen's final before the election
The banners read ‘Marseilles against the extreme right and fascism'.
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A member of a youth communists group, Alan, 23 said: “As a communist I came to lend a hand to an anti-fascist movement.”
Around 10,000 Front National supporters attended the rally, which focused on security and immigration.
Following the protest, the meeting was under high police surveillance.
Two men who were suspected of planning to carry out an ISIS-style attack were arrested in Marseille earlier this week.
Voters in France will head to the polls on Sunday for the first round of the French election.