Loann Goujon and John Barclay have been brought into the France and Scotland sides respectively
Scotland team to face France
Scotland XV: Stuart Hogg; Sean Maitland, Tommy Seymour, Huw Jones, Alex Dunbar; Finn Russell, Greig Laidlaw (captain); Allan Dell, Fraser Brown, Zander Fagerson, Richie Gray, Jonny Gray, John Barclay, Josh Strauss, Hamish Watson.
Replacements: Ross Ford, Gordon Reid, Simon Berghan, Tim Swinson, John Hardie, Alistair Price, Duncan Weir, Mark Bennett.
Finn Russell picked up a knock against Ireland but has recovered to retain his place
Ryan Wilson has been forced to miss the France game with an elbow infection and John Barclay has replaced him at blindside flanker, while John Hardie takes his place on the bench despite having only just made his comeback from a three-month spell recovering from an ankle injury.
Fraser Brown meanwhile has overcome an eye injury to retain his place at hooker in what is likely to be the biggest challenge of his 21-cap career – France demonstrated their set-piece power against England while Allan Dell and Zander Fagerson are by no means Scotland's first-choice props.
France team to face Scotland
France XV: Scott Spedding; Noa Nakaitaci, Remi Lamerat, Gael Fickou, Virimi Vakatawa; Camille Lopez, Baptiste Serin; Cyril Baille, Guilhem Guirado (captain), Uini Atonio, Sebastien Vahaamahina, Yoann Maestri, Loann Goujon, Kevin Gourdon, Louis Picamoles.
Replacements: Christopher Tolofua, Rabah Slimani, Xavier Chiocci, Julian Le Devedec, Damien Chouly, Maxime Machenaud, Jean-Marc Doussain, Yoann Huget.
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Click through the gallery for the most bizarre moments in Six Nations history
France were edged out 19-16 by England at Twickenham as the defending champions struggled to get out of first gear.
But the new-look French side impressed in attack and in the scrum and have only made one alteration to their starting line-up, also at blindside flanker, as Loann Goujon replaces the hugely experienced Damien Chouly.
Loann Goujon is expected to add an extra ball-carrier to the France team against Scotland
"Chouly is their line-out specialist, but Goujon's another ball-carrier, very similar to Louis Picamoles, so it's obvious how they are going to play," said Scotland coach Vern Cotter.
"They're very heavy and powerful, very good going forward, but I want to see how they go when they have to go backwards.
"Turning them round will be key to the game.
"We've got to push them backwards and, if we can do that and force errors out of them, we'll free up the game.
"We have to be smart."