Joyce was in charge of Manchester United's reserves for eight years between 2008 and 2016 before becoming Wigan's manager in November.
The 52-year-old, who will return to Old Trafford on Sunday when the Latics take on Jose Mourinho's men in the FA Cup, oversaw the development of a host of stars within United's youth ranks.
And Wayne Rooney, Paul Pogba and Marcus Rashford stand out in his mind as unique players that have been born with their incredible ability, insisting they can't be compared with any upcoming stars, nor can a coach take credit for their talents.
Warren Joyce is a big fan of Paul Pogba, Wayne Rooney and Marcus Rashford
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Certainly he has God–given talent and has to hone it of course. But any coach who says they have ‘made’ a Pogba, Rashford or a Rooney are deluded
“Take Paul Pogba who I spent two-and-a-half years with the first time at United," Joyce told The Sun.
“I knew then that he was desperate to be a successful player at United, still is.
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“Certainly he has God–given talent and has to hone it of course. But any coach who says they have ‘made’ a Pogba, Rashford or a Rooney are deluded.
“The talent they have is genetic. Pogba has it. He has fantastic physical, technical and mental attitudes.
Warren Joyce returns to Manchester United with Wigan on Sunday in the FA Cup
Paul Pogba has God-given talent, says Warren Joyce
“But he also has a massive heart and that is part of what helps him tick every box.
“You look at them then and look at them now and they pretty much get to where you thought they would.”
All three players are expected to feature in United's second-leg semi-final EFL Cup tie against Hull tomorrow night (7.45pm).