Morgan, 51 – who regularly defends his friend Donald Trump – got into a heated debate with Jefferies, 39, when he insisted that the President's immigration order was "not a Muslim ban".
Jefferies then snapped: “Oh, f**k off. This is what you do, Piers. You say ‘He hasn’t done this, he hasn’t done that, he’s not going to do all these things’.
"Give him a f**king chance mate – Hitler didn’t kill the Jews on the first day, he worked up to it.”
Morgan – who riled up the stars when he called for Maher and anti-Trump Americans to 'take a chill pill' – said that the whole conversation was "ridiculous, hysterical over-the-top nonsense".
Piers Morgan and Jim Jefferies came to blows over Donald Trump
Piers has since taken to Twitter to hit out at the comedian
Oh f**k off!
Jim Jefferies to Piers Morgan
Jefferies then added: “You just like that you won The Apprentice and you have a famous friend, mate.”
Good Morning Britain host Morgan went on to note that the crowd were acting surprised, with him saying: “You’re losing your audience because you’re sounding unpleasant…”
“Am I losing you?” Jefferies then asked, as the audience immediately responded.
As per usual, Morgan was quick to take to Twitter to have his say over the whole thing, with him also responding to a follower's post this morning.
Piers Morgan's most famous Twitter spats
Thu, September 22, 2016
Good Morning Britain host, Piers Morgan's most outrageous quotes and Twitter spats.
1 of 11
Piers Morgan's most outrageous quotes
Jim told Piers to 'f**k off!'
J.K. Rowling waded into the debate on Twitter
Piers insisted Jim had apologised to producers after the heated chat
The fan asked: "Want to hit back at Jim Jefferies?" to which Morgan replied: "No. When they play the Hitler card vs Trump, there's no point."
Another social networker also posted: "The way @jimjefferies completely burned @piersmorgan tonight was pure joy…" but Morgan immediately hit back: "He burned himself. I heard him apologise to producers after the show for losing his temper."
J.K. Rowling waded into the debate as well, with her posting: "Yes, watching Piers Morgan being told to f**k off on live TV is *exactly* as satisfying as I'd always imagined."