The Frenchman has endured plenty of criticism throughout the season after failing to secure Champions League football for the first time during his Arsenal reign.
A seventh consecutive exit in the last-16 of the Champions League also added further pressure on his shoulders.
Arsene Wenger's future has divided opinion throughout the campaign with him yet to announce whether he will sign a new deal or not.
Supporters have taken to protesting in the street, displaying 'Wenger Out' banners at matches, and even flying planes over the Emirates with messages calling for Wenger to leave the club.
Arsene Wenger says he's been hurt by the actions of some Arsenal fans
The lack of respect from some has been a disgrace and I will never accept that. I will never forget it.
And the campaign from some of the Arsenal supporters who want him to leave have clearly hurt the 67-year-old – who says he will never be able to forget the harsh treatment he has received.
"I don't mind criticism because we are in a public job," he told BBC Sport.
"I believe there's a difference between being criticised and being treated in a way that human beings don't deserve.
"The lack of respect from some has been a disgrace and I will never accept that. I will never forget it.
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Arsenal fans have called for Arsene Wenger to leave the club
"The behaviour of some people during the season is what hurts me most. It's not my person that is hurt but the impeccable image of the club around the world. That kind of behaviour does not reflect what Arsenal is.
"A strong club is a club that makes a decision. It is wrong that in modern society it is not a question of whether a decision is right but whether it is popular. That has nothing to do with competence. People with responsibility have to make the right decision."
Wenger will have the chance to put the smiles back on Arsenal fans' faces when they take on Chelsea in the FA Cup final this evening (5.30).