Sigmar Gabriel, the German Minister for Economy and Energy and Vice-chancellor, said those pushing for an exit from the EU were “Europe’s enemies”.
Mr Gabriel, who is standing down as leader of the Social Democrats, warned other European nations against following Britain’s example.
The outgoing minister said in the Bundestag on Thursday: “Mr President, dear colleagues, this is, in fact, not my last speech here but my last speech in the role of Economy Minister for the German Bundestag and I would like to take this opportunity to thank those who went back and forth with me here, often combatively.
“On your side but also, it must be said, from my side there’s a real enjoyment of the debate.
Sigmar Gabriel used his final speech as Economy Minister to take aim at Brexit
If Europe’s enemies, after Brexit, are successful once again we are in danger of seeing the EU fail
“The French Presidential elections and earlier ones are bitter prospective elections for Europe.
"If Europe’s enemies, after Brexit last year, are successful once again, if they’re able to achieve success in France or the Netherlands, then we are really in danger of seeing the largest civilisation project of the 20th century fall apart, namely the European Union.”
Mr Gabriel was also quick to take aim at the rise of populism in global politics, pointing towards Donald Trump’s presidency and its disregard for EU trade deals, instead seemingly favouring bilateral trade deals with Britain.
“What has come to pass in the US and what is also happening in the other countries is extremely dangerous for the global economy and also for us,” he continued.
“Nevertheless, one must not despair, one shouldn’t be fearful nor docile.
"At the moment, short of 10 per cent of German exports go to the US, but 60 per cent goes to Europe.
“And, because of this, it was right to approve the European-Canadian agreement (CETA).
"I am looking beyond, at a time after Donald Trump, who has pronounced protectionism, and had ended TPP, and has calculated that allowing for CETA to fail, from Germany or from Europe, would be more successful. The world would now die of laughing at us for criticism of the USA.”
Mr Gabriel surprised the Bundestag when he announced that he would not run against Chancellor Angela Merkel in September’s federal election.
Instead, he opted to back pro-EU politician Martin Schulz to take over the centre-left Social Democratic Party.
Ms Merkel’s position has come under fire from the right-wing, with Alternative for Germany keen to oust her from Germany’s top role.
Long-time member of the European Parliament Mr Schulz said: “This country needs new leadership in these difficult times.
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“I’m saying to all the populists and extremist enemies of our democracy and our pluralistic values… the fight starts now.”
It is unknown whether Mr Schulz’s potential candidacy will hamper Britain’s European divorce negotiations, but he has become to be known as an anti-Brexit hard-liner in his position of President of European Parliament.
He branded Theresa May’s plan for ‘hard’ Brexit “unacceptable” and said he would vote to veto Britain’s departure if they continued to “cherry pick” the best aspects of EU for their final deal.