David Willey will be out until at least April after having shoulder surgery
Willey played all three of England’s ODIs against India last month but only bowled two overs in the final game in Kolkata and missed the subsequent T20 Internationals.
And the Yorkshire left-arm seamer has now been ruled out until April after he had surgery to repair a partial tendon tear in his shoulder.
Middlesex pace man Steven Finn will replace him in the touring party, who will fly to the West Indies on February 22 ahead of two warm-up games followed by the first ODI on March 3.
Steven Finn has not played ODI cricket for England since 2015
David Willey is an all-rounder but his left-arm seam provides some much needed variety in the attack
England will play the West Indies again on March 5 and March 9 before returning home for ODIs in May against Ireland and South Africa.
Those games will represent England’s final preparation for the ICC Champions Trophy which takes place in June on home soil.
Finn is currently playing in the Pakistan Super League T20 competition for Islamabad United but will hope to capitalise on Willey's injury by securing a spot in the side for the Champions Trophy.
England coach Trevor Bayliss admitted earlier this month he was happy for some of his players to miss time with the team to play in lucrative franchise T20 cricket around the globe such as the Indian Premier League (IPL), but that those less sure of their place should take the chance to play for the national side more seriously.
“We'll look at it on a case-by-case basis," Bayliss said.
"Some of the guys could benefit from playing in the IPL and the experiences that brings with it.
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"But there are the guys who are trying to get into the team and from my point of view, it would good for them to play and show us what they can do in the ODI form of the game."