Maro Itoje has switched to flanker for England
Injuries to Billy Vunipola and Chris Robshaw have left Eddie Jones' ranks in the back row depleted.
Teimana Harrison had been suggested as a potential replacement but England have instead switch 2016 World Rugby Breakthrough Player of the Year Itoje from second row to flanker.
Elliot Daly has kept his place for England despite a red card on his last outing
It means Courtney Lawes will partner Joe Launchbury at lock while James Haskell, who has not played for England since toe surgery last summer, returns to the bench.
Elliot Daly meanwhile has kept his place despite having been sent off five minutes into his last appearance against Argentina during the autumn internationals.
England Rugby's 14-game winning streak
Fri, January 6, 2017
Express Sport recaps England Rugby's unbeaten 2016
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England won every single match they played throughout 2016, and are currently on a 14-game winning run dating back to October 2015
However, Jones has kept faith in the Wasps winger who will win his ninth cap on Saturday.
Daly was picked on the left wing ahead of Jack Nowell, who is on the bench, with Jonny May on the right.
James Haskell has been recovering from an injury sustained in Australia last summer
England XV: Brown, May, Joseph, Farrell, Daly, Ford, Youngs, Marler, Hartley, Cole, Launchbury, Lawes, Itoje, Wood, Hughes.
Replacements: George, Mullan, Sinckler, Harrison, Haskell, Care, Te'o, Nowell.