An unmanned drone targeted a vehicle travelling in Baihan in the Shabwa province of Yemen, in which two suspected member of al Qaeda were travelling, according to local officials.
A civil war in the Middle Eastern country has been ongoing between the Houthi forces and the Saudi-backed government of President Abd-Rabbu Mansour Hadi with al Qaeda and Islamic State also involved in the fighting.
Between March 2015 and January 2017 16,200 people, including 10,000 civilians have been killed, according to United Nations estimates.
A US drone strike on a car in the Yemen in 2015 (archive image)
The US views al Qaeda in the Yemen as a significant threat to its interests in the Middle East and has conducted dozens of drone strikes in the area under the former President Barack Obama.
American defence officials have acknowledged drone strikes but have declined to comment on particular incidents.
A US commando died and three were wounded during a dawn raid on Sunday in the rural Yakla district of central Yemen's al-Bayda province.
US President Donald Trump on the telephone to the Saudi king
The US military also said that at least 14 suspected al Qaeda militants were killed.
At least 10 Yemeni women and children are also believed to have been killed during the dawn raid on Sunday which involved missiles and helicopter machine guns.
A US military official, speaking on the condition of anonymity, said that civilian deaths could not be ruled out and that one US commando had been killed and three others wounded.
Yemen Crisis: 19-month civil war continues
Wed, November 16, 2016
Schools and hospitals have been bombed, children are currently malnourished, the scale of suffering is the result of an ongoing conflict in Yemen. An estimated 10,000 people have been killed, according to the UN. Express Pictures reports the shocking photographs taken from inside the ongoing crisis in Yemen.
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Intensive care wards in Yemen's hospitals are filled with emaciated children hooked up to monitors and drips
Al-Qaeda said Abdulraouf al-Zahab, a senior leader of the group, was killed along with several other fighters in the raid on the area that has been a frequent target of US drone strikes.
Mr Trump called the operation a success and said intelligence gathered during the operation would help the United States fight "terrorism".
He said in a statement: ”Americans are saddened this morning with news that a life of a heroic service member has been taken in our fight against the evil of radical Islamic terrorism.”
A US drone is believed to have killed two al-Qaeda operatives in the Yemen (stock image)
The US President spoke with Saudi Arabia’s King Salman on Sunday in an hour-long telephone conversation and agreed to support safe zones in Syria and Yemen, according to a White House statement.
The pair also agreed to step up counter-terrorism and military co-operation as well as enhance economic ties.
The White House statement said the two also discussed what it called an invitation from the king for Trump "to lead a Middle East effort to defeat terrorism and to help build a new future, economically and socially," for Saudi Arabia and the region.