Donald Trump and Angela Merkel
The pair haven't got off to the best start after the US President blasted the beleagured German leader for "ruining" Germany over her ill-fated refugee policy.
The focus of the conversation is likely to be Russia-Ukraine relations, according to reports.
A source said Mr Trump might want to speak with Mrs Merkel about a lifting of the US sanctions imposed on Russia in response to its intervention in Ukraine.
Angela Merkel has come under fire over her open-door migrant policy
However if such a step was taken, the European Union would not necessarily follow Washington, as its sanctions remain tied to implementation of the Minsk peace deal.
This will add to growing signs Mr Trump's administraion is keen to repair relations with Russia, which had deteriorated under Barack Obama’s leadership.
It remains unknown whether Mrs Merkel will respond to the strong criticism she has recieved from the American leader now that he has taken office.
Donald Trump has previously blamed Mrs Merkel for damaging her own country beyond repair, adding Germans thought it was the "greatest place on Earth" two years but is now a "sad, sad shame".
Trump may want to lift US sanctions against Russia
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Trump speaks briefly to reporters as he arrives aboard Air Force One at Joint Base Andrews
The president also threatened to bin the EU trade deal in his election campaign and it has since emerged any details if TTIP has been wiped from the White House website.
Meanwhile, Frank-Walter Steinmeier, a key ally of the Chancellor warned of “troubled times ahead” and “global disorder” following the election of the business mogul.
Trump is hoping to improve relations with Putin's nation
He did, however, say Germany would work together with the USA – despite their obvious hostility towards him.
Mr Trump will also hold telephone discussions with Russian President Vladimir Putin in a bid to restore US-Russia relations.