The pair shared an extremely tense handshake in front of the world's media before discussing issues effecting Europe.
The presidents were meeting for the first time since Mr Macron's election victory on May 7 – something Mr Trump said was being discussed "all over the world".
The pair discussed terror, the migrant crisis and trade during their meeting in Brussels, Belgium today.
But it was the handshake which drew the most attention, given the importance the former business mogul places on body language.
The US president has become known for his unorthodox handshake style after gripping the Japanese PM’s hands for 19 seconds and facing off with Canadian leader Justin Trudeau.
But the 70-year-old US president was faced with a power struggle when he came face to face with Emmanuel Macron, 39.
Donald Trump and Emmanuel Macron meet for the first time
Mr Macron was clearly prepared for the meeting and gripped Mr Trump’s hand so tight it turned white.
Once the strange handshake was over Mr Trump congratulated Mr Macron for doing a "great job" to win this month's election while Mr Macron said the two men would be able to change many things together.
NATO countries' heads of states gather in Brussels
Thu, May 25, 2017
NATO countries' heads of states and governments gather in Brussels for a one-day meeting
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A family picture during the NATO (North Atlantic Treaty Organization) summit at the NATO headquarters, in Brussels, on May 25, 2017
Mr Trump told Macron it was an honour to meet with him, saying he had run "an incredible campaign and had a tremendous victory".
He said: “All over the world they are talking about it and we have a lot to discuss including terrorism and other things. Congratulations, great job.”
Mr Trump also used his trip to Brussels to express his condolences to the victims of this week’s Manchester attack and to issue a rallying cry to European leaders in the fight against terror.
Donald Trump and Emmanuel Macron shared a tense handshake before their meeting
He said the Manchester attacks were "savage" and "barbaric" and accused low-spending members of NATO of owing "massive amounts of money”.
He said: "We will never waiver in our determination to defeat terrorism and achieve lasting security, prosperity and peace.
"Terrorism must be stopped or … the horror you saw in Manchester and so many other places will continue forever.”