The 50-year-old has penned Saturday's episode of the science-fiction drama, Empress of Mars, which will see the Ice Warriors return once more to fight the Doctor (played by Peter Capaldi).
With the pressure seemingly on to keep the lore of Doctor Who at the forefront of every episode, Mark revealed that he "doesn't give a monkey's" about whether fans get upset.
"Having always been one of those viewers, and also having been in my time a militant fanboy, I don't give a monkey's," he told press.
Mark added: "The people who complain if something contradicts The Wheel in Space are always going to watch the show in order to complain about it.
Mark Gatiss revealed he would have liked to see Capaldi stay on with incoming Chris Chibnall Doctor Who series 10: Episode guide Tue, April 18, 2017
Doctor Who series 10: A Complete episode guide for Peter Capaldi's last series as The Doctor.
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Doctor Who series 10 episode guide
Having always been one of those viewers, and also having been in my time a militant fanboy, I don't give a monkey's
"You only have to worry about the people who didn't know that the show existed before 2010. Or even 2016, effectively.
"It's ancient history – six months is ancient history in television terms.
"I mean there's no point in being perversely cruel and say I'm going to totally rewrite the history of the Daleks… Unless you come up with an idea which is startlingly brilliant," he teased.
Mark also revealed that he has "no idea" who the new Doctor is, but has admitted he would have liked to have seen Peter stay on a bit longer with the incoming head writer, Chris Chibnall.
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Mark's episode, Empress of Mars, airs Saturday on BBC One at 7.15pm
He said: "It's always exciting and a little frightening, but also thrilling because there's all that to look forward to.
"So I can't wait to see who [the new Doctor] is – but I have no idea who it is!
"Part of you, of course, would love to see Peter under Chris Chibnall. You know, David [Tennant] nearly stayed, and David under Steven [Moffat – head writer] for a year would've been such a different beast, its fascinating to think," Mark revealed.