Tottenham are aiming to trim Chelsea's lead at the top of the Premier League table back to four points.
Manager Mauricio Pochettino has opted to recall Kyle Walker, who started the Wembley clash on the bench.
The England international comes in for Kieran Trippier.
And Pochettino has also opted to bring in Ben Davies for Son Heung-Min.
Mauricio Pochettino is hoping Tottenham can close the gap on Chelsea
Crystal Palace, meanwhile, have also made two changes from the team that beat Liverpool 2-1 at Anfield.
Mamadou Sakho returns to the side after missing the clash against the Reds due to terms of his loan deal.
James McArthur has been given the nod by Sam Allardyce with Yohan Cabaye named on the bench.
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Lloris, Walker, Dier, Alderweireld, Vertonghen, Davies, Wanyama, Dembele, Eriksen, Dele, Kane
Subs:Lopez, Trippier, Wimmer, Sissoko, Nkoudou, Son, Janssen
Crystal Palace team:
Hennessey, Ward, Kelly, Cakho, Schlupp, Milivojevic, Puncheon, McArthur, Zaha, Townsend, Benteke
Subs: Speroni, Van Aanholt, Delaney, Cabaye, Sako, Flamini, Campbell