Boris Johnson will spend the weekend considering whether to tighten Covid-19 measures further, after saying the UK was “now seeing a second wave”.
The government is understood to be looking at a ban on households in England mixing, and reducing opening hours for pubs and restaurants.
At least 13.5 million people, roughly one-in-five of the UK population, are already facing local restrictions.
In London, additional measures were “increasingly likely”, its mayor said.
Mr Johnson only has direct power over restrictions in England. The devolved governments in Scotland, Wales and Northern Ireland can set their own rules.
Widespread growth of the virus has been recorded across the country, with cases doubling every seven to eight days.
There were a further 4,322 confirmed cases on Friday – the first time the daily total of positive tests has exceeded 4,000 since 8 May.
Meanwhile, governments across Europe have announced new restrictions to tackle the surge in infections.
Speaking on Friday, Mr Johnson said he did not “want to go into bigger lockdown measures” but that tighter social distancing rules might be necessary.
He added: “Clearly when you look at what is happening, you have got to wonder whether we need to go further than the rule of six that we brought in on Monday.”
The government is understood to be considering a short period of tighter rules across England – “a circuit break” – which could involve closing hospitality venues.
However, schools and workplaces would stay open.
No 10 is also looking at limiting the opening hours of pubs and restaurants across the country, as has already happened in many areas of north-east England, where pubs had to close at 22:00 BST on Friday.
Scottish First Minister Nicola Sturgeon, Welsh First Minister Mark Drakeford, and Labour leader Sir Keir Starmer have all called on the prime minister to hold an emergency Cobra meeting.
Ms Sturgeon said the next few days would be “critical” to avoid another full-scale lockdown in Scotland.
London Mayor Sadiq Khan said he was extremely concerned by evidence of the accelerating speed with which coronavirus was spreading in the capital.
“We will be considering some of the measures which have already been imposed in other parts of the UK,” he said.
“I am of the firm view that we should not wait, as happened six months ago, for this virus to again spiral out of control before taking action.”
The government’s Scientific Advisory Group for Emergencies (Sage) said the R number – representing the number of people an infected person will pass the virus on to – had risen to between 1.1 and 1.4.
Although deaths remain at a very low level, Sage, said the rise in the R number “shows that we are moving to wider spread growth in transmission at a faster rate”.
Public Health England’s medical director Yvonne Doyle warned of “far worse things to come”.
The sharp rise in UK cases over the last two weeks comes amid ongoing problems with the government’s test and trace programme, leading to people struggling to access tests.
‘UK’s trajectory is not written in stone’
The question is no longer where we are, but where we are heading.
Yes, the number of people infected, in hospital with Covid or dying from the disease are all at far lower levels than at the peak.
Scientists will quibble about the exact definition of a “second wave”, but all data points to rising numbers of infections.
The government’s science advisers say the number is now doubling every week.
If those trends continue then infections could go from the estimated 6,000-a-day to more than 100,000 by mid-October.
It is that trajectory, which is not written in stone, the government is trying to change.
There are questions for politicians, from whether it should do a “circuit-break” to improving Test and Trace.
But, with evidence suggesting only one in five people are following the self-isolation rules when they get sick, there are also questions for all of us.
New restrictions for large parts of England’s North West, West Yorkshire and the Midlands come into force on Tuesday.
The latest areas to see extra measures put in place include Lancashire (excluding Blackpool), Merseyside and the Cheshire boroughs of Warrington and Halton.
Additional restrictions are also being put in place in Wolverhampton, Oadby and Wigston in Leicestershire, and all parts of Bradford, Kirklees and Calderdale.
In total, nearly 4.7 million people will be affected by the new restrictions, which ban separate households from meeting each other at home or in private gardens.
- COVID-19 IN WINTER: What will the effect be on the SARs-CoV-2 virus?
- RETURN TO FILMING: How has filming EastEnders changed?