New York Governor Andrew Cuomo has announced one-mile (1.6km) coronavirus “containment zone” around a community north of New York City.
New Rochelle has seen “probably the largest cluster” of US cases, Mr Cuomo said at a news conference on Tuesday.
The state will deploy National Guard troops to clean schools in the city and deliver food to any quarantined individuals.
New York state has 173 active coronavirus cases, the most in the US.
Of these cases, 108 are in Westchester County, where New Rochelle is located. New York City, which is located around 25 miles (40km) south of New Rochelle, has 36 confirmed cases of the virus in its population of eight million people.
Mr Cuomo said there will no travel restrictions in the small city, but large meeting points in the area will be closed.
Schools, gathering places and businesses in the virus hot spot will be closed for two weeks.
There were 804 confirmed cases of coronavirus in the US as of Tuesday afternoon, according to Johns Hopkins University in Maryland, which is tracking the outbreak.
Twenty-eight people have died as a result of the virus – 23 in Washington state, two in California, two in Florida and one in New Jersey.
“It is a dramatic action, but it is the largest cluster in the country, and this is literally a matter of life and death,” Mr Cuomo said, adding that numbers of cases were “going up unabated” in New Rochelle.
“You’re not containing people. You’re containing facilities.”
Officials will also set up a coronavirus testing facility at a local hospital.
New Rochelle has a population of close to 80,000 people.
A synagogue is at the centre of the New Rochelle outbreak, local media report.
A man in his 50s who attended religious services is believed to be “patient zero” in the region. Around 1,000 people associated with the temple are now under quarantine.
President Donald Trump, meanwhile, said he has been told he does not need a coronavirus test after appearing at a conference last month that was attended by an infected individual.
Five senior Republicans, including Mark Meadows – the president’s newly appointed chief of staff – announced they would be self-quarantining after interacting with the unidentified person.
The White House has said Mr Trump did not have direct contact with the patient.
Mr Trump and some of his fellow Republicans have been accused of racism for referring to the disease as the “China Virus” and the “Wuhan virus”.
The disease was widely referred to by those terms after it was first reported in China in December.
But US Centers for Disease Control and Prevention Director Robert Redfield told a congressional hearing on Tuesday that it was wrong to refer to the virus as Chinese.
He pointed out that there are serious outbreaks in many countries.
The president had earlier shared a tweet saying his planned wall at the US-Mexico border would help contain the virus’ spread.
Democratic presidential front-runner Joe Biden responded by saying: “A wall won’t stop a virus. Racism won’t stop a virus. Do your job.”
As the number of cases continues to rise, the US is working to repatriate passengers from the Grand Princess cruise that docked in California yesterday. A total of 21 individuals on the vessel have tested positive for Covid-19 thus far.
Some 140 Britons were on the cruise. The BBC understands the British passengers will be flown out of the US on Tuesday evening.
They will be advised to self-isolate for two weeks upon return to the UK, and the cruise company is expected to arrange transport for them after they land in the UK.