The actor – who has played Nick Tisley since 2009 – wanted to exit the soap to spend more time with his family.
He is due to leave the cobbles during Super Soap Week this summer as drama will begin to unfold as it emerges that Steve McDonald (played by Simon Gregson) is the father of Nick’s on-off lover Leanne Battersby’s (Jane Danson) baby.
His dramatic exit will follow scenes that show Michelle Connor (Kym Marsh) deciding to divorce Steve McDonald over the revelation that he had an affair with Leanne.
The story follows on from the couple’s devastating loss of baby Ruarui who was born prematurely at just 23 weeks into her pregnancy.
Ben Price who stars as Nick Tisley is set to leave Coronation Street
Coronation Street's most dramatic moments
Thu, January 12, 2017
Coronation Street's most dramatic moments.
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Michelle Connor suffered a heartbreaking miscarriage
“Coronation Street has been the most significant part of my career and I have had a fantastic seven years here,” Ben told The Mirror.
The 45-year-old continued: ”The decision to leave is purely personal – I want to be able to spend more time with my family.
"I have been supported by a terrific cast and crew and have had the most glorious storylines and for that I am most grateful.”
The Newcastle-born actor has had to commute to work in Manchester from his London home where he lives with his wife and two children.
Coronation Street Executive Producer Kieran Roberts said to the publication: “We fully respect Ben’s decision to leave Coronation Street.
Nick Tisley struggles to accept Leanne Battersby's revelation about her unborn child
Michelle Connor and Steve McDonald recently lost their son
"He is valued member of cast who will be greatly missed but we still have many months of great storylines with him leading to his dramatic exit later this year.”
The character of Nick – who is the first-born son of Brian Tisley and Gail Platt – has been in the soap since his birth in 1981.
But he has been played by three different actors during his life with Ben’s stint beginning in 2009.
He is the older brother of Sarah and David Platt.
Coronation Street continues tonight at 8.30pm on ITV.