The Stillbirth and neonatal death charity (Sands) was inundated with calls and emails from grieving parents over the course of a two-day period.
According to figures from Sands, between January 11 and 13, when the scenes were broadcast, the charity's helpline saw an increase of 50 to 60 calls.
They also received 100 emails from people getting in touch, which is usually how many they would get over the course of a month.
Speaking exclusively to Express.co.uk, Bereavement Support and Awareness Specialist at Sands, Erica Stewart, said: "We've had contact from long ago bereaved, which is probably [Coronation Street's] main audience, a little bit older people whose babies have died in the 1940s, 50s and 60s."
She continued: "A lot of people have found out about Sands for the first time. Some people think it's too late to get support or too late to contact us because their baby died so long ago. We're here for anyone no matter when their baby died."
Erica worked with the writers of Coronation Street on the initial storyline, which aired two weeks ago and saw Rovers Return landlady (played by Kym Marsh) left grief-stricken after she went into early labour and her son Ruairi died soon afterwards. However, she has not been involved with the scenes set to air this week.
She praised stars Kym, 40, and Simon Gregson, who plays Michelle's husband Steve, for their sensitive portrayals of the storyline and drawing on their own experiences for the painful scenes.
Michelle McDonald lost her baby on Coronation Street
Michelle McDonald is left emotional on Coronation Street
Some people think it's too late to get support or too late to contact us because their baby died so long ago
Bereavement Support and Awareness Specialist at Sands, Erica Stewart
Kym lost her baby son Archie at a similar stage of pregnancy, while Simon, 42, and his wife Emma Gleave went through 11 miscarriages.
"It's been really good and because they've experienced it themselves, they've been able to draw on their own experience. It makes it even more real, more authentic. The audience can feel that," she added.
Tonight Michelle will be consumed with grief and pictures released from the ITV soap have seen her sitting on the edge of a bridge, as she contemplates taking her own life.
Michelle McDonald struggles to come to terms with the loss of her son on Coronation Street
Coronation Street's most dramatic moments
Thu, January 12, 2017
Coronation Street's most dramatic moments.
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Michelle Connor suffered a heartbreaking miscarriage
Reflecting on how bereaved parents have dealt with their grief, Erica explained: "I think with parents, there is no hierarchy, there's no right or wrong way to grieve and some mothers may feel suicidal but it's important to remember that not everybody is the same."
She went on to stress: "I think it's important to remember that not every parent whose baby has died feels that way."
Along with Sands, mothers who may be struggling to cope with the death of their child can contact the Maternal Mental Health Alliance either through the charity's helpline, contacting their local GP or calling the NHS number 111. Erica also suggested that people should speak to the Samaritans.
On whether the Coronation Street plot line would change perceptions and attitudes towards this sensitive issue, Erica said: "Hopefully, the storyline will create the awareness if someone says, 'I had a late miscarriage', the public will understand what that means that it is a baby that has died."
If you have been affected by the storyline, you can find support at www.uk-sands.org or call the national helpline on 020 7436 5881.
For more information about the Samaritans call 116 123 or visit www.samaritans.org.
Coronation Street continues on ITV tonight at 8.30pm.