The two talented defenders have an intense club rivalry with Pique at Barcelona and Ramos at Real Madrid.
They have often exchanged digs between one another this season with both clubs battling for the La Liga title.
But both of them will link up on international duty this weekend for Spain's World Cup qualifier against Israel tomorrow night.
Diego Costa admits Gerard Pique and Sergio Ramos are best friends
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Sergio Ramos and Gerard Pique love each other!
And Costa has let slip that they are in fact best friends.
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In an interview with Spanish publication Cadena Ser, Costa spoke about the Spain team and admitted: "Sergio Ramos and Gerard Pique love each other!"
And ahead of the match tomorrow night Ramos has also confirmed he is looking forward to seeing Pique.
Gerard Pique will meet up with Sergio Ramos and Diego Costa this weekend
Sergio Ramos says he will give Gerard Pique a hug when he sees him
"It's the way it is between Real Madrid and Barcelona and that will not change," the 30-year-old said.
"Now, I will give him a hug. We have become accustomed to throwing stones, but we take it without malice and it is always healthy.
"That serves as something for you to sell. The key is the unity in the team, and that cannot be lost."