Manchester City's star striker has enjoyed a prolific career in England at the Etihad, and even penned a contract extension last summer.
But his position in City's first XIU is under real threat following the arrival of Brazil sensation Gabriel Jesus.
Pep Guardiola opted for the 19-year-old up front at West Ham on Wednesday and he shone in a 4-0 win.
Aguero, 28, has apparently told his advisors he will not accept becoming second choice at City, suggesting his fixture at the club is in doubt.
Sergio Aguero has been at Manchester City since 2011 and has 113 Premier League goals
Real Madrid want to sign the Argentina international this summer too
Express Sport understands Inter Milan are ready to offer him a lucrative move to Italy.
And according to the Mirror, Chelsea will also be major bidders for the £75million-rated hitman.
Real Madrid want to sign the Argentina international this summer too, but Antonio Conte could hijack any potential switch.
Chelsea are still uncertain as to whether Diego Costa will stay at the club for next season
The Chelsea boss is still unclear over the long-term future of Diego Costa at Stamford Bridge.
Despite playing down an exit from west London, Costa has been strongly linked with clubs in China.
As a result, the Blues are exploring their attacking options, with Madrid's Alvaro Morata a reported target too.
Chelsea stars meet Will Ferrell after beating Arsenal
Sat, February 4, 2017
Chelsea stars met Will Ferrell after beating Arsenal at Stamford Bridge
Chelsea FC via Getty Images
1 of 4
Will Ferrell poses with Marcos Alonso and Pedro
Gabriel Jesus scored at West Ham on Wednesday as he was preferred to Sergio Aguero for Man City
Agüero has shown he is a proven goalscorer in the Premier League and could replace the hole that would be left by Costa.
And as he fears Jesus is threatening his integral role in the City team, it may open the door for Aguero leaving.
Guardiola holds the power at the Etihad as to who he wants to keep and offload, and if the City hero fails to regain his place in the side then the boss could be willing to part with him.