Reports first broke out of China this afternoon, where the former Newcastle star is playing for Chiense second-tier side Beijing Enterprises, that he had been taken ill after training.
It appears he was subsequently rushed to hospital, where he was pronounced dead.
His former club Newcastle have released a short statement that reads: "We are devastated to have learnt of the tragic passing of former Newcastle United midfielder Cheick Tiote in China today."
And a spokesman for the player, Emanuele Palladino, said: "It is with deep sadness that I confirm that my client Cheick Tiote sadly passed away earlier today after collapsing in training with his club Beijing Enterprises.
"We cannot say any more at the moment and we request that his family's privacy be respected at this difficult time. We ask for all your prayers."
Cheick Tiote has died aged 30
Newcastle manager Rafa Benitez said: "It is with great sadness that I have this afternoon learned of Cheick's death.
"In the all the time that I have known him, he was a true professional, dedicated and above all, a great man.
"Our hearts go out to his family and friends at such a sad time."
Club captain Jamaal Lascelles said: "There are not words to express how saddened I am to hear the news that Cheick has died this afternoon.
"I have spoken to the team and non of us can believe it, my thoughts are with his family at this time. RIP Cheicky"
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Anderlecht, who first signed Tiote from Ivorian side FC Bibo, wrote: "Another young man taken way too soon… #RIP Cheik Tiote Our thoughts are with his family."
Cheick Tiote played his last game for Newcastle in January this year
His former club TC Twente posted a statement that read: "What a terrible news: Cheick Tiote (30) is today suddenly died. We wish family and survivors much strength."
Tiote won the Eredivisie title with FC Twente in 2010.
FC Twente legend Jan van Halst said: "We are shocked and deeply saddened by his sudden death. Cheick was a great guy and a great professional.
"He was introverted and could enjoy silence of things. As a player Cheick was hard but fair and above all very strong. So we will always remember him at FC Twente.
"We wish family, friends and survivors much strength to process this loss."
Cheick Tiote dead: Clubs and former team-mates pay tribute to ex-Newcastle ace Mon, June 5, 2017
Cheick Tiote has died after collapsing in training, with clubs and former team-mates paying tribute on Twitter to the ex-Newcastle United midfielder
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Following his death, a tragic WhatsApp chat emerged where Tiote described himself as being “all good”.
Tiote appeared in high spirits as he swapped messages with his friend Yusuf Abubakar Tumi.
In it, he enquired about his pal’s health with the pair laughing together over Tiote’s demand for some free watches.
Hours later, it was announced the Beijing Enterprises midfielder had died after he collapsed in training.
The conversation was posted on Twitter by Tumi, who is a verified user.
Tumi starts the conversation saying after Tiote, who is saved in his phone as ‘Cheick T China’.
Tiote responds saying he is “good brother”, before asking after his friend.
Tumi then joked that he needed to get some watches off him to which Tiote responded: “U are the boss. U need to give for free.”
Cheick Tiote joined Newcastle in 2010
Cheick Tiote was part of the Ivory Coast side that won the 2015 Africa Cup of Nations
Tiote made his professional debut for Anderlecht in 2005 before moving to FC Twente three years later.
The defensive midfielder then secured a £3.5million switch to Newcastle in 2010.
He remained at the Magpies for seven years – his sole Premier League goal coming in the 4-4 draw against Arsenal in February 2011.
In 2015 Tiote helped Ivory Coast win the Africa Cup of Nations, having made his international debut in 2009.
Tiote made just 22 appearances of Newcastle's Premier League relegation campaign in 2015/16.
He remained on the periphery of manager Rafa Benitez's plans at the start of last season and played just three times before heading to China.
His last game for the Toon was in a 3-1 win over Birmingham in January.
Cheick Tiote will be fondly remembered for his goal against Arsenal
Ex-Newcastle frontman Peter Lovenkrands told Sky Sports: "I'm still in a bit of a shock, so had to hear about what's happened to Cheick. I was one of his biggest admirers at the club, he was a fantastic player in the squad.
"He was a player who would always give 100 and 10 per cent on the pitch and in training. He was one of the players if you didn't pull your foot away in tackles you would get hurt because he would never hold back. He was always the one who was smiling and joking as well in training.
"One of the fittest guys I've met, he was just relentless that way in training that he was always at the highest level of fitness.
"It's just mind-boggling for me to hear what's happened, especially with a guy who was so fitness-orientated and so sharp in training and in games. That it could happen to him is a bit of a shock."
Cheick Tiote sent St James' Park wild with his goal
Tiote's former team-mate at Newcastle, Demba Ba, tweeted: “may Allah gives grant you jannah brother Tiote.” He included six crying emojis in his post.
While Newcastle legend Steve Harper, who played alongside Tiote, tweeted: "Gutted to hear the awful news about my former teammate Cheik Tiote today. Thoughts with his friends and family."
Jonas Gutierrez, who left Newcastle in 2015, added on Twitter: "Sad news. Always going to be remember our time together at NUFC. RIP my friend."
Ayoze Perez wrote: "I can't belive it. No words. I am broken. RIP Cheick."
Paul Dummet wrote: "Gutted to hear the news. A real nice guy. He helped me a lot as I was breaking into the first team so I can't thank him enough.