The American refuses to back down as she rages at the Apprentice star in a expletive-filled rant.
As she sits in the kitchen alongside Jamie O'Hara talking about the newest additions to the house, the 47-year-old explains: "I don't want them coming in acting like they know what it's been like for the past couple of weeks, acting like they know what we've been through. Telling me that I'm insecure. I don't like that."
Overhearing her comments, Jessica sighs: "Oh my god Stacy!" which doesn't go down too well with the singer.
She hits back: "Don't f***ing talk to me. Don't talk to me. I didn't ask you s***. Don't f***ing talk to me, I'm done with you.
Stacy Francis and Jessica Cunningham CLASH in ANOTHER row
Jessica tries to diffuse the situation as Stacy shouts at her
Celebrity Big Brother 2017 highlights
Tue, January 17, 2017
Celebrity Big Brother 2017: The best bits from the latest series including all the arguments, kisses and Tony the Pony.
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"You don't have a reality on what it's been like in this house. Don't you come in here and tell me that I'm insecure. I'm not insecure.
"You don't know my reality, you have no idea, you came in late in the game and you think you're going to win."
Jessica tries to diffuse the situation, telling her: "If you want to have a conversation, I'll talk. You want to shout at me."
But, Stacy refuses to stop shouting and insists her fellow housemate is being "very disrespectful".
Stacy insists that Jessica is disrespectful towards her
Stacy was removed earlier this week after another argument with Jessica
Later, Jessica explains that she isn't playing a game and simply wants to win "for my character" and because "people think I deserve to win".
It won't be the first time the ladies will have clashed. Stacy was removed from the Celebrity Big Brother house when they argued over which of their lives had been "tougher".
Celebrity Big Brother continues tonight on Channel 5 at 9pm.