In last night's live show, housemates nominated who they would like to be permanently immune from eviction.
The majority of the house chose James Cosmo for eternal immunity, before he condemned the TV duo to face every public vote.
In the smoking area, Nicola, 35, and Coleen Nolan, 51, spoke about James, with Nicola adamant that the 68-year-old should not have picked Speidi, adding that is was the "wrong choice".
In the diary room, James confided in Big Brother, adding: “I just hope it’s not too heated with Heidi and Spencer. The decision I had to make was obviously the wrong one, I didn’t read the situation clearly.
Celebrity Big Brother 2017: Nicola vows 'never to speak' to Speidi again after HUGE clash
Nicola is now blocked on social media when we get out of here. Gone.
"I thought that they would be absolutely fine with leaving, I’ve got it wrong and apologised. I’m not a realty show player.”
Later in the bedroom, Nicola confronted Speidi, saying: "I’ve not once said a negative comment about you.”
Spencer was annoyed that Nicola didn’t pick them for eternal immunity and burst out in a rage about James to Heidi, adding: “He’s a f**king piece of sh*t! We’re two different people, I love you, but I’m going to say what I’m going to say!”
Upset about the situation, Nicola darted for the diary room where she told Big Brother: "I feel so bad that I didn’t pick Heidi and Spencer, now they feel like I’m playing a game against them. I feel uneasy…I really like them. I don’t know how to play this game, I’m a mess!”
Celebrity Big Brother 2017: Spencer and Heidi
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Speaking to Big Brother in the diary room, Spencer, 33, and Heidi, 30, continued: "Nothing surprising… we always said James C is the biggest player in the house!
"James C has chinned us! Nicola is now blocked on social media when we get out of here. Gone. Coleen just beat Chloe and Jedward! Nicola is playing a James C level game, she wants to win.”
At the dining table unable to sleep, Nicola spoke to Jessica, 29, concluding: "I will never speak to them. They can come to me. I’ve not done anything wrong.”
Celebrity Big Brother continues tonight on Channel 5 at 10:30pm.