Britons move an average of 100 miles from where they were born to work
Scotland and Wales are among the top places people move away from, while London is the leading city for "internal migrants".
The capital also has one of the highest number of people moving away, highlighting the transient nature of its population, said family history site Ancestry.
Its survey of 2,000 adults showed a huge shift in people prepared to leave their home area compared with 25 years ago.
Scotland and Wales are among the top places people move away from
Many Brits move for a job or better quality of life
The trend of people moving around within the UK has seen a huge increase over the past few decades
The previous generation lived just five miles from where they born on average, compared with 100 miles now, the study showed.
Other reasons for leaving home included remaining in a university area, or wanting to live in the country.
More than two-thirds of those who move say they will not return.
The survey showed that half of Britons live somewhere different from where they were born, while most of those who stay say they want to be close to their family.
Get Quotes on Home Insurance
The ancestry of Britain Fri, August 14, 2015
An almost unrecognisable Great Britain pictured in the 19th and 20th Centuries.
The Francis Frith Collection 1 of 19
Parliament Square and Big Ben in London, 1965
Brad Argent, of Ancestry, said: "Immigration is something that we hear a lot about, but lesser known is the fascinating trend of people moving around within their own country which has seen a huge increase in the UK over the past few decades.
"With people moving around the country more and more, it means many have deep sense of belonging to places which may not only be different to where they live, but even places that they've never actually been to."