The 57-year-old looked flabbergasted and simultaneously in stitches as he heard the Malawi-born comic – who is Amanda Holden’s Golden Buzzer act this year – make a joke about being a slave.
Daliso, 37, was heard saying as part of his comedy routine: “I’m black, 200 years ago this would have been an auction! We’ve come a long way, that’s all I’m saying!”
His punchline sent the crowd and the judges wild as Simon could not stop laughing and could been seen mouthing: “Wow!”
Even Alesha Dixon could not stop laughing as she stood up to applaud him for his comedy.
Afterwards the panel were full of praise for Daliso as Simon told him: "I love that you are fantastically non-PC.”
Meanwhile, Amanda told him: "I think that is even better than the first time we saw you. You were so on the edge, it was naughty, it was edgy. You smashed it.”
Daliso Chaponda left Simon Cowell in hysterics
The Britain's Got Talent judges were in hysterics
I’m black, 200 years ago this would have been an auction! We’ve come a long way, that’s all I’m saying!
It was revealed that Daliso used to tour with Jack Whitehall, who said the stand-up had never been given his big break.
Judge David vowed that Britain's Got Talent would give Daliso his big break and it appears that his words have come true as the African comedian received the most votes from the public this evening.
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The Britain's Got Talent judges were in hysterics Britain's Got Talent: Most memorable moments Mon, May 1, 2017
Britain's Got Talent: The best and worst moments from the ITV talent show.
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Dance act Just Us get the golden buzzer
Britain's Got Talent act Daliso Chaponda impresses
The two acts will be joining MerseyGirls, The Pensionalities, Kyle Tomlinson, mind reading act DNA, magician Matt Edwards, Issy Simpson, Tokio Myers and comedian Ned Woodman.
The judges are also set to be announcing a wildcard they’ve chosen from the acts that failed to make it through.
Britain’s Got Talent 2017 final will air on ITV tomorrow at 7.30pm.