Ms Morano was the last known survivor of the 19th century.
Her doctor confirmed the news adding that she had died at her home in Italy.
Dr Carlo Bava told The Associated Press by telephone that Morano's caretaker called him to say the woman had passed away Saturday afternoon while sitting in an armchair in her home in Verbania, a town on Lake Maggiore.
Italian Emma Morano has died aged 117
Dr Bava said he had last paid his nearly-daily call on Morano on Friday. He says "she thanked me and held my hand" as usual.
Her doctor of 27 years said that she rarely ate vegetables or fruit.
He said: "When I met her, she ate three eggs per day, two raw in the morning and then an omelette at noon, and chicken at dinner."
Emma Morano has died in Italy aged 117
Emma Martina Luigia Morano was born on 29 November 1899 in Civiasco, Vercelli, Piedmont, Italy.
She was the oldest of eight siblings.
Ms Morano credited her long life to her diet of raw eggs, which she ate three a day, and being single.
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Emma Morano at her home in Italy
Local mayor Silvia Marchionini said:”She had an extraordinary life and we will always remember her strength to help us move forward.”
She was awarded the honour of Knight of Order of Merit of the Italian Republic by President Giorgio Napolitano in 2011.
On 29 July 2016 she was presented with a certificate from Guinness World Records recognizing her as the oldest person alive.
Ms Morano met 11 popes and 12 Italian presidents, she died peacefully in her sleep.