Donald Trump and Angela Merkel
The pair haven't got off to the best start after the US President blasted the beleagured German leader for "ruining" Germany over her ill-fated refugee policy.
The focus of the conversation is likely to be Russia-Ukraine relations, according to reports.
A source said Mr Trump might want to speak with Mrs Merkel about a lifting of the US sanctions imposed on Russia in response to its intervention in Ukraine.
However if such a step was taken, the European Union would not necessarily follow Washington, as its sanctions remain tied to implementation of the Minsk peace deal.
Donald Trump has previously blamed Mrs Merkel for damaging her own country beyond repair, adding Germans thought it was the "greatest place on Earth" two years but is now a "sad, sad shame".
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Trump speaks briefly to reporters as he arrives aboard Air Force One at Joint Base Andrews
Mr Trump will also hold telephone discussions with Russian President Vladimir Putin in a bid to restore US-Russia relations.
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