A cordon is in place on Springfield Street as police and the bomb squad search a house.
it is the second time in a week the street has been closed, after an address in the same location was searched on Thursday.
Some residents have been froced to evacuate their homes while others have been told to stay indoors.
The Royal Logistic Corps bomb disposal unit is currently on the scene.
Surrounding roads have been shut as the operation is underway
The bomb disposal squad have descended on a house in Wigan
A helicopter is also circling the area, as police are believed to be returning the focus to the Wigan property.
The street was evacuated last Thursday after the discovery of "potentially suspicious items".
A man was arrested in Wigan on Wednesday, which led to last Thursday’s raid.
A statement from Greater Manchester Police says: “We are currently searching a property in Springfield Gardens in Wigan in relation to last Monday’s attack on Manchester Arena.
“There is a cordon in place and we are asking people to avoid the area.”
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Surrounding roads have been shut as the operation is underway.
— Paul Doward (@diggerdow) May 30, 2017
Wigan Lane, at the junction of Central Park Way, is currently closed.
Photos from the scene show numerous police vehicles and officers as a group of locals look on.
Police presence has now reduced and residents are being allowed back in their homes.
The bomb disposal unit has left and traffic is being allowed through the area again, although the helicopter remains.
The raids follow extensive searches and arrests in connection with the deadly terror attack at an Ariana Grande concert on May 22 which left 22 people dead and more than 100 injured.
Army bomb disposal unit called in Police raid in Manchester Thu, May 25, 2017
Police have called in the Army bomb disposal squad at a raid in Hulme, Manchester. This is the first deployment of British troops in terror-related investigations
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Army bomb disposal teams arrive in Hulme, South Manchester