The most senior Republican in Congress added that the US did not want to use military options in regard to the reclusive country but that it needed to keep all options open.
He said: “Of course we don't want to have military options employed, but we must keep all options on the table.”
Speaking about the precarious balance in world affairs he also stated he believed that the current nuclear deal with Iran would remain in place but that sanctions would needed to be ratcheted up.
Paul Ryan in London
The 47-year-old was speaking at the Policy Exchange think tank in London also said that the US was ready to forge a new bilateral trade deal with the UK as soon as possible.
The senior member of Donald Trump's Republican party, said that US lawmakers are committed to working with the president towards a bilateral agreement with the UK.
His clear signal provides a significant boost for Theresa May as European Union leaders take the first steps towards agreeing a negotiating position for forthcoming Brexit talks.
Mr Ryan also added that he believed that the UK would be abel to agree a Brexit deal with the European Union.
Photos from North Korea during celebration of the birth of late leader Kim Il Sung
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North Korean leader Kim Jong-Un (R) attending a military parade in Pyongyang marking the 105th anniversary of the birth of late North Korean leader Kim Il-Sung
Paul Ryan with Chancellor Philip Hammond
Mr Ryan said: "Now that Article 50 has been invoked, the UK and the EU will determine the best path forward over the course of these negotiations.
"We want the parties to come together and strike a lasting agreement, a strong UK-EU relationship is in all of our best interests.
"In that same vein, the United States will work closely with our EU friends and chart a path forward on TTIP (Transatlantic Trade and Investment Partnership) negotiations.
"At the same time we are committed to working with President Trump and your Government to achieve a bilateral trade agreement between the United States and Britain.
"This is one of the bipartisan messages I bring with me, I bring Democrats and Republicans here to this room to this country today, to say that the United States stands ready to forge a new trade agreement with Great Britain as soon as possible so that we may further tap into the great potential between our two people."
Paul Ryan (L) with Philip Hammond
Mr Ryan's comments come as the Prime Minister prepares to hold talks on Thursday with Antonio Tajani, the President of the European Parliament, which will ultimately have to approve any post-Brexit deal between the UK and EU.
Answering questions from an audience including International Trade Secretary Liam Fox and other Cabinet ministers, Mr Ryan said he was confident the UK and EU could agree an exit deal.
"This is your country, you make those decisions," he said.
US Speaker Paul Ryan during his visit to London
"But I assume you will get an agreement, I can't imagine you won't, and I just want you to know that as your special ally, as your greatest partner, we're going to stand with you through all of this.
"We think it's in everyone's interests to have a strong relationship between Britain and the EU, we want to, as soon as the UK is ready and able, to do a trade agreement, a bilateral trade agreement."
Mr Ryan added: "I think what we're going through if we handle this correctly will be to bring more prosperity and security to our respective countries."
More to follow…