Marc Bartra misses out after surgery on a broken bone in his wrist following yesterday's attack on the Dortmund team bus.
The Spaniard is replaced by Sven Bender in defence.
Felix Passlack and Christian Pulisic are also left out with Julian Weigl and Shinji Kagawa coming into the side.
Monaco are without defenders Djibril Sidibe and Benjamin Mendy but the talented Kylian Mbappe leads the line alongside Radamel Falcao.
Police snapped outside Borussia Dortmund's training ground after bus attack Wed, April 12, 2017
There was a strong police presence outside Borussia Dortmund's training ground this morning in the aftermath of the attack on their team bus last night
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Police were pictured outside Dortmund’s training ground after the bus attack
Marc Bartra misses out after surgery on his wrist
Borussia Dortmund: Burki, Bender, Dembele, Guerreiro, Aubameyang, Kagawa, Sokratis, Piszczek, Ginter, Schmelzer, Weigl.
Subs: Weidenfeller, Sahin, Mor, Pulisic, Merino, Passlack.
Monaco: Subasic, Toure, Jemerson, Glik, Raggi, Fabinho, Moutinho, Lemar, Silva, Falcao, Mbappe.
Subs: De Sanctis, Jorge, Diallo, N'Doram, Dirar, Germain, Cardona
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