Big Brother presenter Emma Willis, 41, announced the news to the Borehamwood compound during last night's live eviction show, confirming that the 56-year-old housemate had been voted out by the public.
Joe then said his goodbyes before exiting the house to a mixed reaction from the crowd, receiving his fair share of boos.
During his post-eviction interview with Emma, he admitted: "I didn't want to go. I was looking forward to it.
Joe Quaranta became the fifth housemate to be evicted from Big Brother last night
Joe lashed out at the people in the crowd who booed him Big Brother 2017: Saucy antics Fri, June 30, 2017
Big Brother 2017: The sexiest moments from the BB house.
Channel 5 1 of 21
Big Brother 2017: The sexiest moments from the BB house
"What they don't tell you," he continued. "I'm 56 years old and when you go from seven to two, three hours of sleep per night, it's hard. The age gap affects me a lot."
He also called the age difference between him and the majority of his ex-housemates "a problem", adding: "You're shattered, you're mentally drained. They're younger, physically I was drained after five days."
Joe went on to hit back at the negative side of the crowd's reaction to his exit, blasting: "To the ones that cheered, thank you! To the w****rs, you got no idea what it's like in the house!"
He also said he had been 'bullied' because of his age
The latest evictee admitted to being lonely in the house
Shortly after leaving, the latest Big Brother evictee opened up about his experience in the house, telling the Metro: "I think I was the only person in that house from the start that actually got bullied because I'm the older man, and I find that quite disturbing."
He added that he had found the younger housemates difficult to deal with at times, finding himself "physically drained".
Although Joe insisted that he had good fun in the house as well, he confessed to being slightly isolated from the rest of the group, saying: "When I'd be outside having many cigarettes not many of them would come out and speak to me and I found it very lonely."
Big Brother continues tonight at 9pm on Channel 5.