Mr Staley’s comments come as HSBC and UBS have both issued new warnings stating thousands of jobs could be moved out of London as the PM sets out plans for Brexit.
Speaking to the BBC from Davos in the Swiss Alps, home of the annual World Economic Forum, Mr Staley underlined the UK’s importance for Barclays’ operations.
He said: “I think the UK will continue to be the financial lungs for Europe.
"We may have to move certain activities, we may have to change the legal structure that we use to operate in Europe but I think it’s going to be at the margin and will be manageable.”
Jes Staley said London remained vital to operations
I think the UK will continue to be the financial lungs for Europe
Barclays has a banking licence in Dublin and big business in the US. But an upbeat Mr Staley said London remained vital.
He said: “We have a bank subsidiary in Ireland, which is obviously part of the EU. We have the largest credit card operation in Germany, so we have quite a presence in Germany today. We have an office in France.
“We will want to stay engaged and whether we have to route some activities through Ireland or do something in Germany, those are the options that we are looking at. But the bulk of what we do will continue to occur in London, in my view.
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Asked whether the red carpet was now being rolled out to encourage banking business, Mr Staley said: “It is interesting that it wasn’t not too long ago that no one quite wanted a banker in their backyard and, all of a sudden, we’re being invited over for the barbecue.”
Last year he warned the European banking sector was “challenged” following the Brexit vote, after Barclays announced pre-tax profits had tumbled.
Global banks HSBC and UBS said at the World Economic Forum in Davos that each could move 1,000 jobs out of the city.