Barcelona go into the match at the Nou Camp trailing 3-0 from the first leg.
Transfer target Paulo Dybala scored a brace with Giorgio Chellini adding a third to put the Catalan giants to the sword.
All hope is not lost for Barcelona, who famously overcame a 4-0 deficit to beat Paris Saint-Germain 6-1 last month.
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However, Spanish outlet Don Balon claims Lionel Messi is not expecting a miraculous repeat.
The Argentina international is angry with Barcelona’s defence, believing they are not up to scratch.
Juventus eased past Barcelona in the first leg
Though they battled their way to a 3-2 win over Real Sociedad on Saturday, the fact they conceded twice did not please their club talisman.
As a result, Messi believes they need to improve at the back if they are to salvage their Champions League dream.
However, the 29-year-old is not expecting them to make the semi-finals.
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