The Business Secretary said the UK's "deep pool of capital" made it possible for European nations the finance investments "cost effectively".
Speaking to Radio 4's Today programme, he said the UK's trade links with Europe was one of its "most important strengths".
Responding to reports several big banks are set to move staff out of London, he said: "Well I hope that they won't need to do that as Theresa May said in her speech – we want to maintain the strongest possible trading relationship, including in services with the rest of Europe.
"One of the most important strengths of the financial services sector in this country, is that it is good for the whole of Europe.
The Business Secretary has said the Government wants a strong trading relationship with the EU
One of the most important strengths of the financial services sector in this country, is that it is good for the whole of Europe
"Having a deep pool of capital means that it is possible for continental European companies to finance their own investments more cost effectively than if the city didn't have the strength that it has."
The Tory MP said the Government was "totally committed" to ensuring the City of London maintained its "power and influence" in the world after Brexit.
"It is a high national asset that is not just vital in what it contributes in terms of jobs [and] taxes to the economy," he said.
"But it also gives rise to a lot of employment and a lot of success in adjacent areas.
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"For example, in professional services and legal services, when you talk about the city, it's not just in the City of London but in places like Bournemouth and Manchester, where I'm speaking from, there are lots of financial services jobs."
The comments come after HSBC and UBS both announced that they could relocate up to 1,000 jobs last week.
Mr Clark also refused to reveal the Government's stance on Nissan, which announced it will conduct a review of its Sunderland plant after Britain leaves the EU.
When pushed on whether the Government had struck a deal with the car maker over electric car manufacturing, he talked about a proposed "sector deal" on car battery technology.
During the interview, the MP also refused to confirm if there was a failed test launch of a Trident missile.