The 19-year-old replaced Timothy Fosu Mensah in the second half to make his first appearance for the club in the 4-0 win.
Tuanzebe, who was born in the Democratic Republic of Congo, is highly rated within United's academy and has been knocking on the door of the senior squad.
Man United fans laud Anthony Martial for performance against Wigan
Sun, January 29, 2017
Express Sport brings you all the best tweets as Manchester United fans laud Anthony Martial for his performance against Wigan
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Manchester United fans laud Anthony Martial for performance against Wigan
Manchester United's Axel Tuanzebe
The sales of Memphis Depay and Morgan Schneiderlin have opened up a space and manager Jose Mourinho handed Tuanzebe an opportunity to impress.
And the young defender says he took onboard Ibrahimovic's words of wisdom before coming on.
He said: "I was on the touchline.
"I could here Zlatan just say ‘keep it simple, keep it simple’.
"I followed his advice.
"I was waiting for my moment and it finally came."