After playing 120 minutes on Sunday against Manchester City, Wenger has shuffled his team for the game against the Premier League champions.
Kieran Gibbs comes in for Rob Holding with Nacho Monreal dropping to centre-back.
Hector Bellerin replaces Alex Oxlade Chamberlain at right wing-back and Francis Coquelin and Theo Walcott come in for Aaron Ramsey and Olivier Giroud.
For Leicester, Robert Huth comes in for the injured Wes Morgan.
While Leonardo Ulloa replaces Shinji Okazaki.
Arsenal training ahead of Leicester clash Tue, April 25, 2017
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Arsenal were training ahead of their clash with Leicester
The Emirates Stadium
Arsenal: Cech, Gabriel, Koscielny, Monreal, Bellerin, Coquelin, Xhaka, Gibbs, Ozil, Sanchez, Walcott
Subs: Martinez, Ramsey, Elneny, Oxlade-Chamberlain, Iwobi, Welbeck, Giroud
Leicester: Schmeichel, Simpson, Benalouane, Huth, Fuchs, Mahrez, Ndidi, Drinkwater, Albrighton, Ulloa, Vardy
Subs: Zieler, Chilwell, Musa, King, Amartey, Okazaki, Gray