The France international was the subject of a £29.3million offer from Arsenal in 2016.
But Aulas turned down the bid and Lacazette opted to remain with the Ligue 1 club.
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However circumstances now appear to have changed and Aulas says he will not stand in the 25-year-old's way if an opportunity to join a big club comes at the end of the season.
"If one day there is an opportunity, of course, as we did with Sam [Umtiti] and Abi [Eric Abidal] in Barcelona or Karim [Benzema] in Madrid or further in time with Ludo [Giuly] to Monaco, who left, why not?" Aulas told OL TV.
Lyon striker Alexandre Lacazette
"Alex has wanted to play in a great club and Lyon does not object. We are perfectly in line."
Aulas' comments come after Lacazette admitted he needs to leave Lyon to progress.
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Alexandre Lacazette could leave Lyon in the summer
“I think that the right moment has arrived to leave,” Lacazette told French outlet Canal+.
“I think that this summer I will need a change of scenery and discover something else, still with the idea of advancing and progressing in terms of football and as a person.
“I will continue to work, in the hope that good opportunities will come this summer.”