Santi Cazorla and Aaron Ramsey are out injured, while Mohamed Elneny is at the Africa Cup of Nations with Egypt and Granit Xhaka is suspended.
Alex Oxlade-Chamberlian and Francis Coquelin have been named in the Gunners' midfield for today's match at Stamford Bridge.
Arsenal boss Arsene Wenger is confident his midfield can cope against Chelsea
And Wenger is confident the duo have the quality to perform well against Chelsea.
"We are capable but there is always an uncertainty," Wenger told Sky Sports.
Twitter reacts as Arsenal announce side to face Chelsea
Sat, February 4, 2017
Express Sport brings you all the best tweets as Arsenal announce their side to face Chelsea
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Arsenal fans are not happy Lucas isn't playing against Chelsea
"There is a little lack of experience in this position [midfield].
"But overall the quality is there.
"And I think the size of the game will certainly compensate the fact that we have a little bit less "experience and hopefully we can cope with that."