Contests between the two sides have made for blockbuster viewing this season, with Conte and counterpart Jose Mourinho often clashing on the touchline.
United are out for revenge after losing twice to the Blues in both the Premier League and FA Cup already this season.
Antonio Conte believes Chelsea could struggle if Manchester United target Eden Hazard Chelsea line-up predicted to face Manchester United Wed, April 12, 2017
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Their 1-0 defeat at Stamford Bridge last month saw them regularly target Hazard – with Ander Herrera dismissed for a foul on him early on.
And Conte has admitted Chelsea will be powerless if Mourinho opts to repeat the tactic this time around.
"It is very difficult to prepare for this type of situation, we are preparing tactically for this game," the Italian said.
Manchester United have targeted Eden Hazard regularly this season
"This game will be very tough for both teams, the result is very important for us and them.
"But I haven't prepared for this type of situation."
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United are aiming for a first win over Chelsea at Old Trafford since a 3-1 victory back in 2011.
Goals from Chris Smalling, Nani and Wayne Rooney gave the Red Devils the win but the game is famously remembered for a shocking miss by Chelsea's Fernando Torres.