The 41-year-old has slammed his executive order which suspends travellers from seven Muslim-majority countries visiting the US.
The Oscar winning actress believes the ban – which also bars Syrian refugees indefinitely – risks fuelling “extremism abroad”.
She penned an op-ed for the New York Times where she vented her anger over the recent decision.
She said: “Shutting our door to refugees or discriminating among them is not our way, and does not make us safer. Acting out of fear is not our way. Targeting the weakest does not show strength.”
Angelina is the Special Envoy for the United Nations High Commissioner for Refugees
Donald Trump has introduced a ban which suspends travellers from seven Muslim-majority countries
Angelina is known for her humanitarian work as much as her movies and has worked closely to aid Syrian refugees.
She continued: “The truth is that even if the numbers of refugees we take in are small, and we do the bare minimum, we do it to uphold the United Nations conventions and standards we fought so hard to build after World War II, for the sake of our own security.
“If we Americans say that these obligations are no longer important, we risk a free-for-all in which even more refugees are denied a home, guaranteeing more instability, hatred and violence.
“If we create a tier of second-class refugees, implying Muslims are less worthy of protection, we fuel extremism abroad.”
The Maleficent actress, who is the Special Envoy for the United Nations High Commissioner for Refugees, believes the response towards terrorism shouldn’t be measured on fear.
Angelina Jolie has spoken out against President Donald Trump’s travel ban
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Angelina Jolie: The Ambassador Diaries
Tue, September 20, 2016
In addition to her film career, Jolie is noted for her humanitarian efforts, and is most noted for her advocacy on behalf of refugees as a Special Envoy for the United Nations High Commissioner for Refugees (UNHCR).
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US actress and UNHCR special envoy and Goodwill Ambassador Angelina Jolie greets children during a press conference at Al- Azraq camp for Syrian refugees.
“The global refugee crisis and the threat from terrorism make it entirely justifiable that we consider how best to secure our borders,” she wrote.
“Every government must balance the needs of its citizens with its international responsibilities. But our response must be measured and should be based on facts, not fear.”
The UN ambassador has six children with estranged husband Brad Pitt from various countries and said she wants the US to be safe for them and refugee children who qualify for asylum.
Her comments come after her father actor Jon Voight – who is a big Donald Trump supporter – condemned Hollywood stars for voicing their opinions over the president and accused some of “teaching treason”.